Significant role of poloxamer in drug transport across blood-brain barrier / 药学学报
Acta Pharmaceutica Sinica
;
(12): 890-897, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232672
ABSTRACT
Poloxamers are found to be an efficient adjuvant with multiple effects and are applied generally in pharmaceutical field. In recent years, it is investigated that poloxamers can increase the permeability of a broad spectrum of drugs through blood-brain barrier (BBB) by means of manifold mechanisms included (1) inhibiting P-glycoprotein and multidrug-resistance associated protein efflux systems on BBB; (2) adsorbing different apolipoproteins in plasma on the surface of poloxamer-coated nanoparticles, which could interact with BBB through different receptors and mechanisms; (3) connecting to specific ligands and monoclonal antibodies to cross the BBB via specific endogenous transporters localized within the brain capillary endothelium. Significant roles of poloxamer in drug transport across BBB are considered in this review which provides for important guidance to the design of brain-targeted drug delivery system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Pharmacology
/
Brain
/
Drug Carriers
/
Blood-Brain Barrier
/
Chemistry
/
Drug Delivery Systems
/
ATP-Binding Cassette Transporters
/
ATP Binding Cassette Transporter, Subfamily B
/
Poloxamer
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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