Hepatitis Viral Infection and Carotid Intima-Media Thickness
Journal of the Korean Neurological Association
;
: 544-549, 2006.
Article
in Korean
| WPRIM
| ID: wpr-23276
ABSTRACT
BACKGROUND:
Carotid atherosclerosis has been known to be associated with systemic inflammatory status. The present study aimed to investigate the relationship between hepatitis viral infection or vaccination and carotid atherosclerosis in a relatively healthy population.METHODS:
A cross-sectional study was performed in 281 subjects (mean age+/-SD, y; 43.8+/-7.2) in the Chonbuk national university hospital. All the participants were examined for the carotid intima-media thickness (IMT) in both common carotid, carotid bulb, and internal carotid arteries. Hepatitis B surface antigen (HBsAg) and IgG antibodies against hepatitis B and C virus (anti-HBs and anti-HCV) were determined by enzyme linked immunosorbent assays.RESULTS:
Twelve subjects (4.3%) were HBsAg seropositive and 6 (2.1%) were anti-HCV positive but the positivity did not affect the mean carotid IMT. However, the hepatitis B-exposure group including both the HBsAg positive and anti-HBs positive without vaccination history showed a significantly higher carotid IMT (mean+/-SD, mm; 0.757+/-0.107 vs. 0.728+/-0.105, P=0.031), even after adjusting for the potential confounders. And, in the subgroup having anti-HBs, the carotid IMT was lower in the hepatitis B vaccinated subjects than in the others (0.725+/-0.103 vs. 0.760+/-0.111, P=0.019).CONCLUSIONS:
Subjects exposed to the hepatitis B pathogen, even though they had anti-HBs, showed the higher carotid IMT, and the participants with a vaccination history demonstrated the lower IMT values. Subsequent study in a large representative population might be needed to further delineate the characteristic associations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin G
/
Carotid Artery Diseases
/
Carotid Artery, Internal
/
Cross-Sectional Studies
/
Vaccination
/
Carotid Intima-Media Thickness
/
Hepatitis
/
Hepatitis B
/
Hepatitis B Surface Antigens
/
Antibodies
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2006
Type:
Article
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