Association of T393C single nucleotide polymorphism of GNAS1 gene with non-valvular atrial fibrillation / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the association between T393C single nucleotide polymorphism (SNP) of GNAS1 gene and non-valvular atrial fibrillation (AF) in Chinese Han patients.</p><p><b>METHODS</b>Ninety patients with non-valvular AF and 90 healthy subjects were examined for T393C SNP of GNAS1 gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The allele genotypes and the distribution of allele frequencies were analyzed and compared between the two groups. The relationship between allele frequency distribution characteristics and the heart rate variability (HRV) were also studied for analysis of the association between T393C SNP of GNAS1 gene and the autonomic nervous activation in non-valvular AF.</p><p><b>RESULTS</b>The two groups showed a significant difference in the frequencies of genotypes of T393C SNP of GNAS1 gene and allele frequencies (P<0.01). CC genotype and T393C allele frequency were significantly increased in the case group. pNN50, LF, or LF/HF showed no significant difference between different genotypes (P<0.05).</p><p><b>CONCLUTIONS</b>The T393C SNP of GNAS1 gene is closely associated with non-valvular AF in Chinese Han patients.</p>