Radioprotective effect of catechines against radiation injury in mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the radioprotective effect of catechines against radiation injury in mice.</p><p><b>METHODS</b>Catechines were administered in mice intragastrically at the daily dose of 200 mg/kg for 10 consecutive days before whole body irradiation with 6 Gy X-rays. The body weight changes, survival time, 30-day survival rate, and counts of peripheral white blood cells were recorded.</p><p><b>RESULTS</b>The mice with catechine pre-treatment before X-ray exposure suffered less body weight loss than those without the treatment before exposure. Catechines markedly increased the survival time of the irradiated mice, and raised the 30-d survival rate of the irradiated mice to 53.33% as compared with the rate of 13.33% in the radiated mice without catechine pre-treatment. Catechines significantly promoted recovery of peripheral white blood cells.</p><p><b>CONCLUSION</b>Catechines have definite radioprotective effect against radiation injury in mice.</p>