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Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat / 药学学报
Acta Pharmaceutica Sinica ; (12): 1268-1272, 2011.
Article in Chinese | WPRIM | ID: wpr-232999
Responsible library: WPRO
ABSTRACT
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Spectrophotometry, Infrared / X-Ray Diffraction / Blood / Ticlopidine / Male / Calorimetry, Differential Scanning / Pharmacokinetics / Platelet Aggregation Inhibitors / Random Allocation Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rats / Spectrophotometry, Infrared / X-Ray Diffraction / Blood / Ticlopidine / Male / Calorimetry, Differential Scanning / Pharmacokinetics / Platelet Aggregation Inhibitors / Random Allocation Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2011 Type: Article