Advances in the research of pregnane X receptor and constitutive androstane receptor / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1173-1177, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-233016
ABSTRACT
Nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are originally characterized as transcription factors regulating many target genes. Recent works have revealed that these nuclear receptors play critical roles in regulating genes that encode drug metabolism enzymes and modulating hepatic energy metabolism, such as down-regulating gluconeogenesis, fatty acid oxidation, and ketogenesis, as well as up-regulating lipogenesis. Studies on PXR and CAR have important implication on drug-drug interaction (DDI) and potential disease treatment targets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Receptors, Steroid
/
NF-kappa B
/
Receptors, Cytoplasmic and Nuclear
/
Glucose-6-Phosphate
/
Drug Interactions
/
Energy Metabolism
/
Lipid Metabolism
/
Glucose
/
Inflammation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS