Prediction of the pharmacokinetic drug-drug interaction of pravastatin and pitavastatin with cyclosporine by a digital liver model based on metabolism and transporter / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1108-1116, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-233026
ABSTRACT
Information of metabolic enzymes and transporters, physiological parameters of animals and demography of Chinese people were integrated to establish a digital liver model (DLM) based on metabolism and transporter and coded with VBA. Clearance and drug-drug interaction (DDI) of candidate drugs in animal and human could be predicted based on the pharmacokinetic data obtained from in vitro and in vivo experiments. Pravastatin and pitavastatin were selected as the samples to examine this model, where their clearance and their DDI with cyclosporine were predicted. The results showed that the predicted values of median parameters in same species were within twofold of observed values for 83.3% (5/6). The program's successful prediction in DDI tendency might indicate its application in optimizing the dosage regimen and reducing the risk of clinical trial.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quinolines
/
Biological Transport
/
Blood
/
Computer Simulation
/
Pharmacokinetics
/
Metabolic Clearance Rate
/
Pravastatin
/
Cyclosporine
/
Area Under Curve
/
Drug Interactions
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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