Synthesis and biological evaluation of sorafenib thiourea derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1093-1097, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-233030
ABSTRACT
Basing on the market multi-target antitumor agent sorafenib, a series of sixteen 4-[4-(2-methyl-aminoacyl-pyridyl)]oxylphenyl aryl thiourea derivatives were designed and synthesized. Their structures were identified by the spectra of 1H NMR, MS and elemental analysis. The evaluation of antitumor bioactivities in vitro was done by MTT method. It was shown that the synthesized compounds had antitumor activities and compounds 1a, 1d, 1i and 1j showed better or equal antitumor activity on sorafenib.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenylurea Compounds
/
Thiourea
/
Molecular Structure
/
Chemistry
/
Niacinamide
/
Cell Line, Tumor
/
Cell Proliferation
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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