Diterpene constituents of Tripterygium willfordii (II) / 药学学报
Acta Pharmaceutica Sinica
;
(12): 942-945, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-233072
ABSTRACT
In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Triterpenes
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Plant Roots
/
HL-60 Cells
/
K562 Cells
/
Tripterygium
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2011
Type:
Article
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