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Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 422-427, 2012.
Article in English | WPRIM | ID: wpr-233142
ABSTRACT
This study examined the effects of combined administration of tyrosine, lecithin, L-glutamine and L-5-hydroxytryptophan (5-HTP) on heroin withdrawal syndromes and mental symptoms in detoxified heroin addicts. In the cluster-randomized placebo-controlled trial, 83 detoxified heroin addicts were recruited from a detoxification treatment center in Wuhan, China. Patients in the intervention group (n=41) were given the combined treatment with tyrosine, lecithin, L-glutamine and 5-HTP and those in the control group (n=42) were administered the placebo. The sleep status and the withdrawal symptoms were observed daily throughout the study, and the mood states were monitored pre- and post-intervention. The results showed that the insomnia and withdrawal scores were significantly improved over time in participants in the intervention group as compared with those in the control group. A greater reduction in tension-anxiety, depression-dejection, anger-hostility, fatigue-inertia and total mood disturbance, and a greater increase in their vigor-activity symptoms were found at day 6 in the intervention group than in the control group (all P<0.05). It was concluded that the neurotransmitter-precursor-supplement intervention is effective in alleviating the withdrawal and mood symptoms and it may become a supplementary method for patients' recovery from heroin addiction.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Substance Withdrawal Syndrome / Therapeutics / Placebo Effect / Single-Blind Method / Administration, Oral / Treatment Outcome / Neurotransmitter Agents / Dietary Supplements / Diagnosis / Drug Therapy Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Female / Humans / Male Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Substance Withdrawal Syndrome / Therapeutics / Placebo Effect / Single-Blind Method / Administration, Oral / Treatment Outcome / Neurotransmitter Agents / Dietary Supplements / Diagnosis / Drug Therapy Type of study: Controlled clinical trial / Diagnostic study Limits: Adult / Female / Humans / Male Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2012 Type: Article