Paclitaxel induced apoptotic genes and pathways alterations: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 153-160, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-233259
ABSTRACT
Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Signal Transduction
/
NF-kappa B
/
Paclitaxel
/
Apoptosis
/
Phosphatidylinositol 3-Kinases
/
MAP Kinase Signaling System
/
P38 Mitogen-Activated Protein Kinases
/
Drug Therapy
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2013
Type:
Article
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