The receptors and entry of measles virus: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1-9, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-233275
ABSTRACT
Measles virus is an enveloped virus with a non-segmented negative-sense RNA genome. Two envelope glycoproteins on the viral surface, namely hemagglutinin (H) and membrane fusion protein (F), are responsible for the virus entry into susceptible host cells. The specific interaction between H and its cellular receptors is a key step in successful virus infection, determining the infectivity and tissue tropism of the measles virus. Thus far, three H receptors have been identified, including the complement regulatory molecule CD46, the signaling lymphocyte activation molecule (SLAM) and the cell adhesion molecule Nectin-4. Here, we reviewed our molecular understanding on the recognition mechanism of these receptors by the viral H protein, aiming to promote future studies on antiviral drug design and measles virus-based oncolytic therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Receptors, Virus
/
Virulence
/
Antigens, CD
/
Cell Adhesion Molecules
/
Receptors, Cell Surface
/
Membrane Cofactor Protein
/
Membrane Fusion Proteins
/
Signaling Lymphocytic Activation Molecule Family Member 1
/
Hemagglutinins, Viral
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2013
Type:
Article
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