Technique of detection of hepatitis C core antigen used in safety blood transfusion / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 617-618, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-233533
ABSTRACT
This study was purposed to investigate the feasibility to screen donor with HCV infection by means of HCV-cAg ELISA. The first and repeat assays were performed for detection of serum anti-HCV in 8677 donor's serum specimens from January 2003 to December 2005. All serum anti-HCV specimens with positive anti-HCV from first and repeat assays were finally identified by using HCV-cAg ELISA and HCV RT-PCR methods. The results showed that only 5 serum specimens were positive anti-HCV by HCV-cAg ELISA identification in 29 specimens including 15 specimens with positive ant-HCV in first assays and 14 specimens with positive anti-HCV in repeat assays, the positive rate detected by HCV cAg ELISA was 17.24%. 5 serum specimens were positive anti-HCV by HCV RT-PCR detection also in 29 specimens mentioned above, the positive rate detected by HCV RT-PCR was 17.24% too. It is concluded that sensitivity of HCVcAg ELISA is similar to HCV RT-PCR and may be useful for the early diagnosis of hepatitic C or used as a reliable method to screen donor with HCV infection in blood transfusion medicine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Blood Donors
/
Blood Transfusion
/
Enzyme-Linked Immunosorbent Assay
/
Viral Core Proteins
/
Hepacivirus
/
Hepatitis C Antigens
/
Reverse Transcriptase Polymerase Chain Reaction
/
Methods
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article
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