Expression and role of beta-catenin in acute leukemia bone marrow cells / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 460-463, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-233568
ABSTRACT
The aim of this study was to explore the expression of beta-catenin in acute leukemia bone marrow cells and its role in the development of acute leukemia. The expression of beta-catenin of bone marrow cells was detected by immunocytochemistry and flow cytometry in 20 cases of newly diagnosed acute leukemia. Meanwhile the expression of the proliferating index Ki-67 was detected by immunocytochemistry. The results showed that the expression of beta-catenin and Ki-67 in acute leukemia bone marrow cells was significantly higher than those in control group (P < 0.05). The migration of beta-catenin from cytoplasm to nuclear was observed in acute leukemia bone marrow cells. There was a positive correlation between the expressions of beta-catenin and Ki-67 in all the cases and the Pearson correlation coefficient was 0.845. In conclusion, the expression of beta-catenin was significantly high in acute leukemia bone marrow cells and showed a positive correlation with the cell proliferation. It suggests that beta-catenin may be involved in the development of acute leukemia through promoting the excessive proliferation of cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bone Marrow Cells
/
Immunohistochemistry
/
Leukemia
/
Acute Disease
/
Ki-67 Antigen
/
Beta Catenin
/
Flow Cytometry
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article
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