Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 413-415, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-233578
ABSTRACT
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Repressor Proteins
/
Hematopoietic Stem Cells
/
Nuclear Proteins
/
Cell Differentiation
/
Cell Division
/
Proto-Oncogene Proteins
/
Cell Biology
/
Polycomb Repressive Complex 1
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article
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