ERCC1 as a Predictive Marker for FOLFOX Chemotherapy in an Adjuvant Setting
Annals of Coloproctology
;
: 92-97, 2015.
Article
in English
| WPRIM
| ID: wpr-23359
ABSTRACT
PURPOSE:
The purpose of this study was to identify the excision repair cross-complementation group 1 (ERCC1) as a predictive marker for FOLFOX adjuvant chemotherapy in stages II and III colon cancer patients.METHODS:
A total of 166 high risk stages II and III colon cancer patients were retrospectively enrolled in this study, and data were collected prospectively. They underwent a curative resection followed by FOLFOX4 adjuvant chemotherapy. We analyzed ERCC1 expression in the primary colon tumor by using immunohistochemical staining. The oncological outcomes included the 5-year disease-free survival (DFS) rate. The DFS was analyzed by using the Kaplan-Meier method with the log-rank test. A Cox proportional hazard model was used for the prognostic analysis.RESULTS:
ERCC1-positive expression was statistically significant in the older patients (P = 0.032). In the multivariate analysis, the prognostic factors for DFS were female sex (P = 0.016), N stage (P = 0.009), and postoperative carcinoembryonic antigen level (P = 0.001), but ERCC1 expression was not a statistically significant prognostic factor for DFS in the univariate analysis (P = 0.397). The 5-year DFS rate was not significantly associated with the ERCC1 expression in all patients (P = 0.396) or with stage III disease (P = 0.582).CONCLUSION:
We found that ERCC1 expression was not significantly correlated with the 5-year DFS as reflected by the oncologic outcomes in patients with high-risk stages II and III colon cancer treated with FOLFOX adjuvant chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carcinoembryonic Antigen
/
Proportional Hazards Models
/
Multivariate Analysis
/
Prospective Studies
/
Retrospective Studies
/
Chemotherapy, Adjuvant
/
Colon
/
Colonic Neoplasms
/
Disease-Free Survival
/
DNA Repair
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Annals of Coloproctology
Year:
2015
Type:
Article
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