Clinical features of 35 cases of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 3-5, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-233637
ABSTRACT
<p><b>OBJECTIVE</b>To realize the clinical features of autoimmune hepatitis-primary biliary cirrhosis (AIH+PBC) overlap syndrome.</p><p><b>METHODS</b>We analyzed and compared the biochemistry, autoimmune antibodies, and liver biopsy results of 129 autoimmune hepatic disease cases retrospectively, using the international criteria to see which could be diagnosed as AIH/PBC overlap syndrome.</p><p><b>RESULTS</b>Our 35 AIH+PBC overlap syndrome patients were mainly women, with a sex ratio of 1 female 10 male, and a median age of 50.79+/-11.27 (20 to 70 years old). They had AIH characteristics such as flare of ALT, AST and elevated immunoglobulin G (IgG), gamma-immunoglobulin. There were also antinuclear antibodies (74.3%); moderate or severe periportal or periseptal lymphocytic infiltration, piecemeal necrosis, and florid bile duct lesions, high serum levels of ALP, presence of mitochondrial antibodies (68.6%) and M2 antibodies (45.7%), and features of PBC.</p><p><b>CONCLUSIONS</b>AIH+PBC overlap syndrome is not rare. It should be diagnosed in time and to find effective treatments for it.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Ursodeoxycholic Acid
/
Blood
/
Immunoglobulin G
/
Cholagogues and Choleretics
/
Retrospective Studies
/
Hepatitis, Autoimmune
/
Therapeutic Uses
/
Diagnosis
/
Drug Therapy
Type of study:
Diagnostic study
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2005
Type:
Article
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