Effect of the drug-resistant attenuated Bacillus proteus on CD80 and CD86 protein expression in peripheral blood dendritic cells of hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 801-803, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-233679
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of the drug-resistant attenuated Bacillus proteus on the protein expression of CD80 and CD86 in peripheral blood dendritic cells (DCs) of hepatitis B patients.</p><p><b>METHOD</b>Peripheral blood monocytes were isolated from HBV-infected patients and the DCs were separated and induced to differentiate in vitro. The expression of CD80 and CD86 proteins on cultured DCs were examined using flow cytometry.</p><p><b>RESULTS</b>The expression rate of CD80 and CD86 of chronic hepatitis B patients increased significantly (P=0.000), while the positive expression rate of CD80 and CD86 showed no obvious variation in healthy individuals (P=0.185 and P=0.118, respectively).</p><p><b>CONCLUSIONS</b>Bacillus proteus can significantly increase CD80- and CD86-positive cell percentage in peripheral blood DCs of HBV-infected patients, but has no such an effect in healthy individuals.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacillus
/
Dendritic Cells
/
Vaccines, Attenuated
/
Case-Control Studies
/
Gene Expression Regulation
/
B7-1 Antigen
/
Drug Resistance, Bacterial
/
Allergy and Immunology
/
B7-2 Antigen
/
Hepatitis B
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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