Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 685-688, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-233710
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of ZNF217 expression to the carcinogenesis and progression of human ovarian cancer.</p><p><b>METHODS</b>Immunohistochemistry and real-time RT-PCR were used to detect ZNF217 expression in human ovarian cystadenocarcinoma, ovarian cystadenoma and normal ovary tissues.</p><p><b>RESULTS</b>The expression levels of ZNF217 protein and mRNA in ovarian cystadenocarcinoma was significantly higher than those in matched ovarian cystadenoma and normal tissues (P<0.05). No significant difference was found in the expression between ovarian cystadenoma and normal ovarian tissues (P>0.05). The mRNA expression in the specimens was consistent with the protein expression of ZNF217 (P<0.05).</p><p><b>CONCLUSION</b>ZNF217 gene expression is closely correlated to the occurrence and clinical stages of ovarian carcinomas, suggesting that ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Pathology
/
Time Factors
/
Gene Expression Regulation, Neoplastic
/
Trans-Activators
/
Disease Progression
/
Reverse Transcriptase Polymerase Chain Reaction
/
Cystadenocarcinoma
/
Genetics
/
Neoplasm Staging
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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