Screening and preliminary analysis of the apoptosis- and proliferation-related genes in nasopharyngeal carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 645-647, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-233720
ABSTRACT
<p><b>UNLABELLED</b>To screen and analyze the apoptosis- and proliferation-related genes in human nasopharyngeal carcinoma (NPC).</p><p><b>METHODS</b>According to gene ontology classification, the abnormal expressions of the genes related to cell apoptosis and proliferation were identified in the NPC gene chip data. The cell apoptosis- and proliferation-related genes expressed in each of the 3 stages, as defined by the tree model for the pathogenesis and progression of NPC, were screened, and with literature review, their distribution in the tree model were analyzed.</p><p><b>RESULTS</b>Nineteen genes related to cell apoptosis were found in NPC, among which 9 were down-regulated (such as DNASE1L3) and located in the chromosome deletion regions, and 10 were up-regulated (such as DEDD) in the chromosome amplification regions. Twenty-one cell proliferation-related genes were identified, including 8 down-regulated genes (such as TUSC2) in the chromosome deletion regions and 13 up-regulated ones (such as EMP1) in the chromosome amplification regions. In the chromosome deletion regions, the down-regulated cell apoptosis-related genes participated mostly in inducing and regulating cell apoptosis, and the up-regulated cell proliferation-related genes in the chromosome amplification regions were mostly associated with the positive regulation of cell proliferation.</p><p><b>CONCLUSION</b>NPC occurs possibly through two pathways by inhibiting cell apoptosis or by promoting excessive cell proliferation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Down-Regulation
/
Up-Regulation
/
Nasopharyngeal Neoplasms
/
Chromosome Deletion
/
Apoptosis
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Cell Proliferation
/
Genetics
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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