Expression of special AT-rich sequence-binding protein mRNA and its clinicopathological significance in non-small cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 534-537, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-233741
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of AT-rich sequence-binding protein (SATB1) mRNA in non-small cell lung cancer (NSCLC) and explore the role of SATB1 in the development of NSCLC.</p><p><b>METHODS</b>The total RNA was extracted from NSCLC tissues and normal lung tissues and reverse transcribed into cDNA. Real-time fluorescence quantitative RT-PCR was performed for detecting the expression of SATB1 mRNA these tissues.</p><p><b>RESULTS</b>The expression of SATB1 mRNA was 13-fold higher in NSCLC tissues than in normal lung tissues (P<0.001), and in metastatic and nonmetastatic NSCLC, the expression was 23.63 and 5.57 folds that in normal lung tissues, respectively.</p><p><b>CONCLUSION</b>SATB1 mRNA expression might be associated with the development and lymph node metastasis of NSCLC and may potentially used as an indicator for predicting the prognosis of NSCLC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
RNA, Messenger
/
Carcinoma, Non-Small-Cell Lung
/
Reverse Transcriptase Polymerase Chain Reaction
/
Matrix Attachment Region Binding Proteins
/
Genetics
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS