A Case of Tuberculosis-associated Hemophagocytic Syndrome during Antituberculosis Medication for Tuberculous Pericarditis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 522-526, 2008.
Article
in Korean
| WPRIM
| ID: wpr-23399
ABSTRACT
A 63-year old woman was admitted to our hospital for an evaluation of thrombocytopenia. She had been diagnosed with tuberculous pericarditis three months earlier in a local clinic and treated with anti-tuberculosis medication. Two months later, thrombocytopenia developed. The medication was subsequently stopped because it was suspected that the anti-tuberculosis medication, particularly rifampin, might have caused the severe platelet reduction. However, the thrombocytopenia was more aggravated. A bone marrow biopsy was performed, which showed moderate amounts of histiocytes with active hemophagocytosis. This finding strongly suggested that the critical thrombocytopenia had been caused by hemophagocytic syndrome, not by the side effects of the anti-tuberculosis medication. Furthermore, the development of hemophagocytosis might have been due to an uncontrolled tuberculosis infection and its associated aberrant immunity. Therefore, she was started with both standard anti-tuberculosis medication and chemotherapy using etoposide plus steroid. One month after the initiation of treatment, the thrombocytopenia had gradually improved and she was discharged in a tolerable condition. At the third month of the follow-up, her platelet level and ferritin, the activity marker of hemophagocytic syndrome, was within the normal range.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pericarditis, Tuberculous
/
Reference Values
/
Rifampin
/
Thrombocytopenia
/
Tuberculosis
/
Biopsy
/
Blood Platelets
/
Bone Marrow
/
Follow-Up Studies
/
Lymphohistiocytosis, Hemophagocytic
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2008
Type:
Article
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