Effect and risk analysis of misoprostol in stimulating cervical maturity for post-term pregnancy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 182-188, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-234166
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect and risk of misoprostol for stimulating cervical maturity in women with post-term pregnancy negative for insulin-like growth factor binding protein-1 (IGFBP-1) in cervical secretion with modified Bishop score less than 3.</p><p><b>METHODS</b>Seventy-one women with post-term pregnancy randomized into misoprostol group (n=37) and control group (n=34) received misoprostol placement at the posterior vaginal fornix and routine intravenous oxytocin infusion, respectively, to stimulate cervical maturity. Failure to respond to the treatment within the initial 24 h necessitated a repeated administration for no more than 3 times in all. Modified Bishop score was recorded and fetal heart monitored once every 24 h, and IGFBP-1 in the cervical secretion was detected at 24 and 48 h after drug administration.</p><p><b>RESULTS</b>The misoprostol group showed better effect of cervical maturity stimulation than the control group (P<0.001), and the positivity rates of IGFBP-1 24 and 48 h after drug administration were significantly higher than that of the control group (P<0.01 and 0.001). The number of cases with indication for cesarean section was significant higher in the control group (P<0.001). There were no significant differences in postpartum hemorrhage, excessive uterine contraction, incidence of fecal contamination of the amniotic fluid or Apgar score of the newborn between the two groups (P>0.05).</p><p><b>CONCLUSIONS</b>Misoprostol is safe and effective for stimulating cervical maturity in women with post-term pregnancy who have modified Bishop score lower than 3 and are negative for IGPBF-1 in cervical secretion. Oxytocin is not advised for use in such gravida for stimulating cervical maturity. IGFBP-1 in cervical secretion may serve as an important index for evaluating the cervical maturity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Administration, Intravaginal
/
Heart Rate, Fetal
/
Pregnancy, Prolonged
/
Abortifacient Agents, Nonsteroidal
/
Cervix Uteri
/
Treatment Outcome
/
Misoprostol
/
Insulin-Like Growth Factor Binding Protein 1
/
Cervical Ripening
/
Therapeutic Uses
Type of study:
Controlled clinical trial
/
Etiology study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
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