Changes of platelet aggregation function of apheresis collected platelets and soluble P-selectin during storage / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1188-1191, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-234270
ABSTRACT
The objective of this study was to explore the changes of aggregation function of apheresis platelets and soluble P-selectin (sP-selectin) during storage. 20 samples of apheresis platelets were collected, and the aggregation function were examined by function test and the level of sP-selectin every day in storage of 5 days. The results showed that the aggregation function of platelets declined obviously during storage, there were significant differences between the first-day group and any of the other groups (p < 0.01). The max platelet aggregation rate was < or = 3% in the fourth-day group; sP-selectin level in plasma increased with prolong of storage time; there were significant differences between the first-day group and any of the other groups (p < 0.05). In conclusion, platelets were activated continuously during storage, while its aggregation function declines significantly. The ability of platelet aggregation to response to ADP loses almost completely since the fourth day during platelet storage. It should be paid more attention to the damage of apheresis collected platelets during storage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Platelet Count
/
Specimen Handling
/
Blood
/
Blood Platelets
/
Platelet Aggregation
/
Plateletpheresis
/
P-Selectin
/
Metabolism
/
Methods
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
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