Expression of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1100-1102, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-234291
ABSTRACT
The objective of this study was to investigate the expressions of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia (CAA) and their significance. The mRNA expressions of EPO, SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were detected by semi-quantitative RT-PCR. The results showed that the levels of EPO, SCF and GM-CSF in CAA patients were obviously lower than those in the healthy individuals (p < 0.01). It is concluded that the immunity disorder mediated by hematopoietic cytokines is one of the pathogenesis in the CAA patients, it provided theoretical basis for guiding clinical treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bone Marrow
/
RNA, Messenger
/
Chronic Disease
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Erythropoietin
/
Stem Cell Factor
/
Genetics
/
Anemia, Aplastic
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
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