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Research progress in roles of microRNA in polyglutamine diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 406-409, 2010.
Article in Chinese | WPRIM | ID: wpr-234395
ABSTRACT
Polyglutamine (Poly Q) diseases are a group of neurodegenerative disorders, caused by the formation of PolyQ mutants due to trinucleotide repeats expansion in coding regions of disease-causing genes, which eventually lead to selective neuronal degeneration and death with unclarified pathogenesis. As a new type of genetic regulatory factor, microRNA (miRNA) plays an important role in modulating gene expression in eukaryote. During the recent years, more attention was paid to roles and related mechanism of miRNA involving in neurodegenerative disease, especially PolyQ diseases. This review is focused on research progress in roles of miRNA in the pathogenesis of PolyQ diseases.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Physiology / Trinucleotide Repeats / Neurodegenerative Diseases / Trinucleotide Repeat Expansion / MicroRNAs / Eukaryota / Genetics / Nerve Degeneration Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides / Physiology / Trinucleotide Repeats / Neurodegenerative Diseases / Trinucleotide Repeat Expansion / MicroRNAs / Eukaryota / Genetics / Nerve Degeneration Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2010 Type: Article