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Effect of Shuangshen Tongguan Recipe on nuclear factor-kappa B signal pathway and myocardial junction-mediated intercellular communication in acute myocardial ischemia/reperfusion injured model rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 228-231, 2005.
Article in Chinese | WPRIM | ID: wpr-234905
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Shuangshen Tongguan Recipe (SSTG) on myocardial nuclear factor-kappa B (NF-kappaB) signal pathway, expression of myocardial junction intercellular communication (MJIC) connexin 43 (Cx43), and infarcted myocardial size and weight of the rats' heart after acute myocardial ischemia/reperfusion (I/R) damage.</p><p><b>METHODS</b>Model rat of I/R injury was established by coronary arterial ligating/ releasing. The infarcted myocardial size and weight were determined by N-BT staining, expression of NF-kappaB p65 in myocardial tissue and Cx43 were determined by immunohistochemical method, contents of serum tumor necrosis factor-alpha(TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) were measured by ABC-ELISA.</p><p><b>RESULTS</b>The myocardial infarcted size and weight, expression of NF-kappaB p65, contents of serum TNF-alpha and ICAM-1 of I/R injured rats in the model group were significantly increased (P<0.05), while Cx43 degraded markedly after modeling. These changes were restored after treated with SSTG (P <0.05).</p><p><b>CONCLUSION</b>Serious myocardial infarction occurs after ischemia/reperfusion injury, combined with NF-kappaB signal pathway activation and severe Cx43 degradation. SSTG could inhibit the activation of NF-kappaB, the over-excretion of TNF-alpha and ICAM-1 in serum, and the degradation of Cx43 to decrease the myocardial infarcted size and weight.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Physiology / Blood / Drugs, Chinese Herbal / Myocardial Reperfusion Injury / Signal Transduction / NF-kappa B / Rats, Sprague-Dawley / Connexin 43 Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Physiology / Blood / Drugs, Chinese Herbal / Myocardial Reperfusion Injury / Signal Transduction / NF-kappa B / Rats, Sprague-Dawley / Connexin 43 Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2005 Type: Article