Investigation of mRNA expression of collagen genes in oral squamous cell carcinoma and paired normal tissue / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1197-1199, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-235164
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mRNA expression of collagen genes in oral squamous cell carcinoma (OSCC) and paired normal oral mucosal tissue.</p><p><b>METHODS</b>The differential mRNA expressions of collagen genes between 30 OSCC tissues and the paired normal oral mucosal tissues were detected by RT-PCR.</p><p><b>RESULT</b>The relative expression level of COL1A1 mRNA in the 30 cancerous tissues was up-regulated by 2.78 folds as compared with its expression in the paired normal samples, suggesting its significant overexpression in OSCC (P<0.001). The expression levels of COL1A2, COL4A1, COL4A2, and COL5A2 mRNA in the cancerous tissues were up-regulated by 1.07, 1.15, 1.27, and 1.16 folds compared to those in paired normal samples (P>0.05).</p><p><b>CONCLUSION</b>COL1A1 mRNA overexpression may play an important role in the carcinogenesis of OSCC and can be a potential molecular marker of OSCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Collagen
/
Collagen Type I
/
Genetics
/
Metabolism
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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