Your browser doesn't support javascript.
loading
Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction / 南方医科大学学报
Journal of Southern Medical University ; (12): 1142-1145, 2011.
Article in Chinese | WPRIM | ID: wpr-235177
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction (CI).</p><p><b>METHODS</b>In the venous blood samples from 250 patients with cerebral infarction and 250 control samples, the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR-sequencing. SHEsis software was used to analyze the association between the results of genotyping and the occurrence of CI.</p><p><b>RESULTS</b>The cerebral infarction group and the control groups showed significant differences in the allele and genotype frequencies of rs189897 and rs2212020 (P<0.05). The A-C haplotype was the protective factor against CI, and the subjects with the haplotype had a lowered risk for CI than those without this haplotype (0.131).</p><p><b>CONCLUSION</b>rs189897 and rs2212020 in ITGA9 gene are closely related to CI, and its A-C haplotype is the protective factor against CI.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Haplotypes / Integrins / Cerebral Infarction / Polymorphism, Single Nucleotide / Alleles / Genetics / Genotype Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Haplotypes / Integrins / Cerebral Infarction / Polymorphism, Single Nucleotide / Alleles / Genetics / Genotype Type of study: Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2011 Type: Article