Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1142-1145, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-235177
ABSTRACT
<p><b>OBJECTIVE</b>To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction (CI).</p><p><b>METHODS</b>In the venous blood samples from 250 patients with cerebral infarction and 250 control samples, the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR-sequencing. SHEsis software was used to analyze the association between the results of genotyping and the occurrence of CI.</p><p><b>RESULTS</b>The cerebral infarction group and the control groups showed significant differences in the allele and genotype frequencies of rs189897 and rs2212020 (P<0.05). The A-C haplotype was the protective factor against CI, and the subjects with the haplotype had a lowered risk for CI than those without this haplotype (0.131).</p><p><b>CONCLUSION</b>rs189897 and rs2212020 in ITGA9 gene are closely related to CI, and its A-C haplotype is the protective factor against CI.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Integrins
/
Cerebral Infarction
/
Polymorphism, Single Nucleotide
/
Alleles
/
Genetics
/
Genotype
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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