Role of miR-145 in erectile dysfunction in diabetic rats / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the role of miR-145 in the corpus cavernosum smooth muscle tissue in the pathogenesis of erectile dysfunction (ED) in diabetic rats.</p><p><b>METHODS</b>The total RNA was extracted from the corpus cavernosum of a diabetic rat model with ED, diabetic rats with normal erectile function and normal rats, and the expression levels of miR145 were compared between the groups.</p><p><b>RESULTS</b>The expression of miR-145 was decreased in the corpus cavernosum of diabetic rats with ED.</p><p><b>CONCLUSION</b>Diabetes mellitus can cause ED in rats, in which process decreased expression of miR145 in the corpus cavernosum may play a role.</p>