Roles of potassium channel in effects of resveratrol on isolated myocardial contractility and heart rate research in guinea pig / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1317-1319, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-235213
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of resvaratrol derivatives on spontaneous HR and CF of isolated guinea pig atrium.</p><p><b>METHOD</b>The dose-effect curve of resvaratrol was observed. The possible mechanism of potassium channels responsible for changes of CF and HR after administering with resvaratrol was measured.</p><p><b>RESULT</b>Resvaratrol reduced the spontaneous HR and weakened the CF in a dose-dependent manner ranging from 10(-6) to 3 x 10(-4) mol x L(-1) (P < 0.05). As compared with Res group, the effects were partly blocked by Gli (P < 0.05) and TEA (P < 0.01), but not blocked by 4-AP, BaCl2, Atropine.</p><p><b>CONCLUSION</b>Resvaratrol can induce negative chronotropic action and negative (inotropic action. The mechanism(s) may relate to the opening of K(ATP) and Kc(Ca).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Stilbenes
/
In Vitro Techniques
/
Cardiotonic Agents
/
Chemistry
/
Chlorides
/
Glyburide
/
Barium Compounds
/
Tetraethylammonium
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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