Effects of micrometer compound rhizoma coptidis on nuclear factor-kappaB and inflammatory factors in rabbit fed with high lipid diet / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1207-1210, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-235232
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of the micrometer compound rhizoma coptidis on inflammatory factors and its possible mechanism in rabbit fed with high-lipid food.</p><p><b>METHOD</b>The levels of CRP, IL-1 and TNF-alpha were all determinated by ELISA method. The mRNA and activity of NF-kappaB were determinated by RT-PCR and EMSA, respectively.</p><p><b>RESULT</b>The level of CRP, IL-1 and TNF-alpha were significantly increased by feeding for 16 weeks with high-lipid diet in rabbit. It was significantly increased that the mRNA and the binging activity with DNA of NF-kappaB in thorax aorta of rabbits fed by high-lipid diet, too. The micrometer compound rhizoma coptidis can reverse the effects of high-lipid diet on CRP, IL-1, TNF-alpha and NF-kappaB.</p><p><b>CONCLUSION</b>The micrometer compound rhizoma coptidis can inhibit the expression of inflammatory factor possibly through inhibitting the expression and activity of NF-kappaB.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Thoracic
/
Particle Size
/
Pharmacology
/
Plants, Medicinal
/
Powders
/
Blood
/
C-Reactive Protein
/
RNA, Messenger
/
Enzyme-Linked Immunosorbent Assay
/
Drugs, Chinese Herbal
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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