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Effect of Xinmaitong capsule on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 850-852, 2007.
Article in Chinese | WPRIM | ID: wpr-235306
ABSTRACT
<p><b>OBJECTIVE</b>To observe the influence of Xinmaitong capsule (XMT) on serum matrix metalloproteinases-9, high sensitive C-reactive protein levels in patients with acute coronary syndrome.</p><p><b>METHOD</b>63 cases were divided by randomized, contrastive assigned to XMT group (n = 31) and control group (n = 32). The serum levels of MMP-9 and hs-CRP before and after treatment in 12 weeks were detected.</p><p><b>RESULT</b>After treatment, the serum levels of MMP-9 in control group had no changed and the levels of hs-CRP reduced. The serum levels of MMP-9 and hs-CRP in XMT group had significantly decreased. The serum levels of MMP-9 and hs-CRP had positive correlation, but had no correlation to levels of serum lipids.</p><p><b>CONCLUSION</b>XMT decreased breakdown of matrix collagen, and inflammatory reaction in the patients of ACS, which may have effect on plaque stabilization.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Triglycerides / Blood / C-Reactive Protein / Capsules / Drugs, Chinese Herbal / Chemistry / Cholesterol / Matrix Metalloproteinase 9 / Therapeutic Uses Type of study: Controlled clinical trial Limits: Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Triglycerides / Blood / C-Reactive Protein / Capsules / Drugs, Chinese Herbal / Chemistry / Cholesterol / Matrix Metalloproteinase 9 / Therapeutic Uses Type of study: Controlled clinical trial Limits: Aged / Female / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2007 Type: Article