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Regulation of E-cadherin promoter activity by LMO2 impact on the progression and metastasis of prostate cancer / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 385-389, 2013.
Article in Chinese | WPRIM | ID: wpr-235352
ABSTRACT
<p><b>OBJECTIVE</b>To study the abnormal expression of the proto-oncogene LMO2 affect the progression and metastasis mechanism of prostate cancer.</p><p><b>METHODS</b>A series of reporter gene expression vectors carrying different lengths and point mutations of E-cadherin promoter were constructed. These plasmids were separately co-transfected with LMO2 into Lncap cells and the luciferase activity was detected after 24 h.</p><p><b>RESULTS</b>The overexpression of LMO2 could significantly inhibit the activity of luciferase reporter gene of E-cadherin promoter about 50%. Truncated and point mutation study showed that this was mainly through E-box sites in the promoter region -204/-198.</p><p><b>CONCLUSION</b>The proto-oncogene LMO2 can affect the progression and metastasis mechanism of prostate cancer by transcriptional inhibition of E-cadherin.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostatic Neoplasms / Cadherins / Proto-Oncogene Proteins / Promoter Regions, Genetic / Point Mutation / Cell Line, Tumor / Adaptor Proteins, Signal Transducing / LIM Domain Proteins / Genetic Vectors Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prostatic Neoplasms / Cadherins / Proto-Oncogene Proteins / Promoter Regions, Genetic / Point Mutation / Cell Line, Tumor / Adaptor Proteins, Signal Transducing / LIM Domain Proteins / Genetic Vectors Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2013 Type: Article