The effect of exercises on TNF-alpha, IL-6 and adiponectin in different fat diet rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 280-282, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-235380
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the role of serum tumor necrosis factor-alpha (TNF-alpha) and adiponectin on insulin resistance in different fat diet rats.</p><p><b>METHODS</b>Thirty weanling female rats were randomly divided into 3 group (n = 10) a low-fat soybean oil (LFS; 22% of total energy fed as fat), high-fat soybean oil (HFS; 40% of total energy fed as fat), or high-fat soybean oil and swimming training at the same time (HFS + T). After fed for 10 weeks, the level of TNF-alpha, adiponectin in serum of rats were observed.</p><p><b>RESULTS</b>(1) The body weight, percentage of body fat of HFS group increased compared with that of LFS group (P < 0.05), however those of HFS + T group were decreased (P < 0.05). (2) The level of serum insulin and ISI in HFS group were increased by LFS group (P < 0.05), in HFS+ T group the levels decreased. (3) And the serum level of TNF-alpha and IL-6 in HFS group were higher than those in LFS group (P < 0.05), the serum levels of adiponectin in HFS group were lower than those in LFS rats, and in HFS+ T group the levels of TNF-alpha and IL-6 were lower than those in HFS group (P < 0.05), the adiponectin level was higher than that in HFS group, and there were no significant difference between LFS group and HFS + T group.</p><p><b>CONCLUSION</b>Exercises training could improve sugar and fat metabolism disorders, which also contributes to improving insulin resistance caused by high-fat diet.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Conditioning, Animal
/
Blood
/
Dietary Fats
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
Adiponectin
/
Diet, High-Fat
/
Insulin
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2013
Type:
Article
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