Choline promotes angiogenesis in chick embryo chorioallantoic membrane / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 229-231, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-235393
ABSTRACT
<p><b>OBJECTIVE</b>To investigate choline promoting angiogenesis on chick embryo chorioallantoic membrane (CAM).</p><p><b>METHODS</b>CAM model was prepared, the choline chloride, human vascular endothelial growth factor (hVEGF) and normal saline were added respectively onto the carrier on the CAM, the state of angiogenesis was observed and the number of new blood vessels was counted.</p><p><b>RESULTS</b>Choline chloride was tested at the concentrations of 0.5 nmol/L - 1 mmol/L in this experiment, when its concentrations were increased to 0.01 micromol/L - 1 000 micromol/L, it could stimulate angiogenesis, the minimum effective concentration was tested as 0.01 micromol/L, and its effect for promoting the angiogenesis was equivalent to that of hVEGF, the potent stimulator for angiogenesis.</p><p><b>CONCLUSION</b>The result shows that choline can promote angiogenesis in the chick embryo chorioallantoic membrane.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Choline
/
Neovascularization, Physiologic
/
Chorioallantoic Membrane
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS