Testing immunogenicity of recombinant antibody by surface plasmon resonance / 药学学报
Yao Xue Xue Bao
; (12): 532-535, 2013.
Article
in Zh
| WPRIM
| ID: wpr-235632
Responsible library:
WPRO
ABSTRACT
With the development of bio-technological drugs, drug immunogenicity evaluation has become key factor of clarifying safety and efficacy of these drugs. It has become the focus to establish a stable and reliable evaluation system. Due to the advantages such as continuous real-time monitoring, surface plasmon resonance (SPR) technology has been widely used in bio-technological drugs immunogenicity assessments. Our study applied this technology to detect anti-drug antibody (ADA) of a recombinant human anti-rabies monoclonal antibody NM57 in the sera of 48 volunteers admitted in phase I clinical trials. This method could satisfy the basic requirements of detection of ADA.
Full text:
1
Index:
WPRIM
Main subject:
Rabies virus
/
Blood
/
Recombinant Proteins
/
Antibodies, Anti-Idiotypic
/
Surface Plasmon Resonance
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Allergy and Immunology
/
Antibodies, Monoclonal
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Antibodies, Viral
Limits:
Humans
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
2013
Type:
Article