Recent progress of the aptamer-based antiviral drugs / 药学学报
Acta Pharmaceutica Sinica
; (12): 447-456, 2013.
Article
in Zh
| WPRIM
| ID: wpr-235644
Responsible library:
WPRO
ABSTRACT
Aptamers are capable of binding a wide range of biomolecular targets with high affinity and specificity. It has been widely developed for diagnostic and therapeutic purposes. Because of unique three dimensional structures and cell-membrane penetration, aptamers inhibit virus infection not only through binding specific target, such as the viral envelope, genomic site, enzyme, or other viral components, but also can be connected to each other or with siRNA jointly achieve antiviral activity. Taking human immunodeficiency virus and hepatitis C virus as examples, this paper reviewed the effects and mechanisms of aptamers on disturbing viral infection and replication steps. It may provide an insight to the development of aptamer-based new antiviral drugs.
Full text:
1
Index:
WPRIM
Main subject:
Antiviral Agents
/
Oligodeoxyribonucleotides
/
Pharmacology
/
Virus Replication
/
Viral Envelope Proteins
/
HIV
/
Genome, Viral
/
Hepacivirus
/
RNA, Small Interfering
/
Therapeutic Uses
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article