Relationship between expression of somatostatin receptors subtype 2 mRNA and estrogen and progesterone receptors in breast cancer / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1850-1853, 2003.
Article
in English
| WPRIM
| ID: wpr-235864
ABSTRACT
<p><b>OBJECTIVES</b>To observe the expression of somatostatin receptor subtype 2 (SSTR2) mRNA, and investigate the relationship between the expression of SSTR2 mRNA and the expressions of estrogen and progesterone receptors (ERs and PRs) in benign and malignant breast tissues.</p><p><b>METHODS</b>Samples from a total of 23 breast carcinomas, 16 mammary hyperplasias, and 9 mammary fibroadenomas were analyzed. SSTR2 mRNA expression was examined by in situ hybridization using multiphase oligoprobes. ER and PR expressions were detected by immunohistochemical staining. A computerized image analysis system was utilized to estimate the relative content of SSTR2 mRNA.</p><p><b>RESULTS</b>The rate of expression (87.0%) and relative content (0.47) of SSTR2 mRNA in breast cancer were higher than those in benign breast tissue (64%, 0.26) (P < 0.05). SSTR2 mRNA expression was closely correlated with ER and PR expressions in breast cancer (P < 0.05). SSTR2 mRNA was also positively correlated with ER expression in benign breast tissues.</p><p><b>CONCLUSIONS</b>SSTR2 mRNA expression is higher or in benign breast tissues than in malignant ones. There is a significant positive correlation between SSTR2 mRNA and ER and PR expressions. Combined antiestrogen and somatostatin analogue in treatment of ER-positive breast cancers should be further investigated.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Diseases
/
Breast Neoplasms
/
RNA, Messenger
/
Immunohistochemistry
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Chemistry
/
Receptors, Somatostatin
/
In Situ Hybridization
/
Genetics
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article
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