IL-10 polymorphism is associated with increased incidence of severe sepsis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1756-1759, 2003.
Article
in English
| WPRIM
| ID: wpr-235885
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether three biallelic polymorphisms at positions -592, -819 and -1082 in the promoter region of the IL-10 gene are associated with increased incidence of severe sepsis.</p><p><b>METHODS</b>The IL-10 -592, -819 and -1082 polymorphisms were typed using polymerase chain reaction followed by digestion with the restriction enzymes RsaI, MaeIII and MnlI, respectively.</p><p><b>RESULTS</b>Patients with severe sepsis were more likely to have IL-10 -1082 allele 1, compared with controls (P < 0.05). Genotype distribution of the IL-10 -1082 polymorphism significantly differed between patients and controls (P < 0.05). However, the allele frequencies and genotype distribution of the IL-10 -1082 polymorphism did not differ between surviving and dead patients (P > 0.05). No significant differences in the genotype distribution and allele frequencies of the IL-10 -592 and IL-10 -819 polymorphisms were observed between patients with severe sepsis and healthy controls, nor between surviving and dead patients (P > 0.05).</p><p><b>CONCLUSIONS</b>The polymorphism at position -1082 in the promoter region of the IL-10 gene may be associated with susceptibility to severe sepsis. In contrast, the other two highly linked IL-10 polymorphisms are not associated with incidence or the outcome of severe sepsis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Promoter Regions, Genetic
/
Interleukin-10
/
Sepsis
/
Genetic Predisposition to Disease
/
Disease Susceptibility
/
Alleles
/
Genetics
Type of study:
Incidence study
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article
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