Effect of cryopreservation of bone marrow stromal cells on periodontal tissue regeneration / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 246-247, 2008.
Article
in Zh
| WPRIM
| ID: wpr-235931
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of cryopreservation on bone marrow stromal cells' (BMSC) capability of enhancing periodontal regeneration.</p><p><b>METHODS</b>Twenty-six artificial periodontal defects were established in 5 Beagle dogs and divided into 3 groups at random. Only collagen membrane, the complex of cryopreserved and un-cryopreserved BMSC and collagen scaffold were transplanted in the blank control group, cryopreserved and un-cryopreserved groups respectively. The periodontal regeneration was observed 8 weeks after transplantation.</p><p><b>RESULTS</b>The percentage of periodontal regeneration in cryopreserved and un-cryopreserved groups was significantly greater than that of the blank control group (P < 0.05), but no statistical difference was found between cryopreserved and un-cryopreserved groups.</p><p><b>CONCLUSIONS</b>Cryopreservation had no significant negative effects on BMSC capability of enhancing periodontal regeneration.</p>
Full text:
1
Index:
WPRIM
Main subject:
Periodontal Diseases
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General Surgery
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Transplantation, Autologous
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Bone Marrow Cells
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Cryopreservation
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Bone Marrow Transplantation
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Guided Tissue Regeneration, Periodontal
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Cell Biology
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Methods
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Stomatology
Year:
2008
Type:
Article