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Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 4006-4012, 2013.
Article in English | WPRIM | ID: wpr-236114
ABSTRACT
<p><b>BACKGROUND</b>Glutamic acid decarboxylase antibody (GADA) and protein tyrosine phosphatase antibody (IA-2A) are two major autoantibodies, which exert important roles in the process of type 1 diabetes mellitus (T1D). Our study aimed to investigate the changes in positivity and titers of GADA and IA-2A during the course of Chinese acute-onset T1D patients and their relationships with clinical features.</p><p><b>METHODS</b>Two hundreds and forty-seven Chinese newly diagnosed acute-onset T1D patients were consecutively recruited. GADA and IA-2A were detected at the time of diagnosis, one year later, 3-5 years later after diagnosis during the follow-up; all the clinical data were recorded and analyzed as well.</p><p><b>RESULTS</b>During the course of acute-onset T1D, the majority of patients remained stable for GADA or IA-2A, however, a few patients changed from positivity to negativity and fewer patients converted from negativity to positivity. The prevalence of GADA was 56.3% at diagnosis, decreasing to 50.5% one year later, and 43.3% 3-5 years later while the corresponding prevalence of IA-2A were 32.8%, 31.0% and 23.3%, respectively. The median GADA titers were 0.0825 at diagnosis, declining to 0.0585 one year later and 0.0383 3-5 years later (P < 0.001), while the corresponding median titers were 0.0016, 0.0010, 0.0014 for IA-2A, respectively. Fasting C-peptide (FCP) and postprandial C-peptide 2 hours (PCP2h) levels of GADA or IA-2A negativity persistence patients were higher than those of positivity persistence and negativity conversion patients (P < 0.05) which indicated GADA or IA-2A negativity persistence T1D patients had a less loss of β cell function.</p><p><b>CONCLUSION</b>Our data suggest that repeated detection of GADA and IA-2A are necessary for differential diagnosis of autoimmune diabetes and the indirect prediction of the β cell function in Chinese patients.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Glycated Hemoglobin / Protein Tyrosine Phosphatases / Therapeutic Uses / Asian People / Diabetes Mellitus, Type 1 / Drug Therapy / Allergy and Immunology / Glutamate Decarboxylase / Metabolism / Antibodies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Glycated Hemoglobin / Protein Tyrosine Phosphatases / Therapeutic Uses / Asian People / Diabetes Mellitus, Type 1 / Drug Therapy / Allergy and Immunology / Glutamate Decarboxylase / Metabolism / Antibodies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Chinese Medical Journal Year: 2013 Type: Article