Effect of Jinguo Weikang Capsule on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 212-216, 2008.
Article
in English
| WPRIM
| ID: wpr-236264
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Jinguo Weikang Capsule [see text] on the gene expression of H-ras, epidermal growth factor receptor (EGFR), P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions, and to investigate the action mechanism of JWC on gastric precancerous lesions.</p><p><b>METHODS</b>A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation. Rats were divided into the normal group, model group, high-, medium-, low-dose JWC treatment groups, and the vitacoenzyme control group, and were treated for 30 days. The expression of H-ras, EGFR, P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods.</p><p><b>RESULTS</b>The expression and over-expression rates of H-ras, EGFR, P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group.</p><p><b>CONCLUSION</b>JWC can inhibit the expression of the H-ras, EGFR, P53 and C-myc genes expression of the gastric mucosa in rats, which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Precancerous Conditions
/
Drugs, Chinese Herbal
/
Immunohistochemistry
/
Gene Expression Regulation, Neoplastic
/
Tumor Suppressor Protein p53
/
Proto-Oncogene Proteins c-myc
/
Proto-Oncogene Proteins
/
Rats, Sprague-Dawley
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2008
Type:
Article
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