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The effect of niflumic acid in hypoxic hypercapnia pulmonary vasoconstriction / 中国应用生理学杂志
Article in Chinese | WPRIM | ID: wpr-236381
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of chloride channel blocker--niflumic acid (NFA) on the pathological process of hypoxia hypercapnia-induced pulmonary vasoconstriction in rats.</p><p><b>METHODS</b>We used the model of hypoxia hypercapnia-induced pulmonary vasoconstriction rats, and divided the second, third branch pulmonary artery rings randomly into four groups (n = 8) control group (N group), hypoxia hypercapnia group (H group), DMSO incubation group (HD group), niflumic acid group (NFA group). Under acute hypoxia hypercapnia conditions, we observed the effects of the three stages of hypoxia hypercapnia-induced pulmonary vasoconstriction (HHPV) incubated by NFA in the second, third brach pulmonary artery rings. At the same time, the values of rings' tension changings were recorded via the method of hypoxia hypercapnia conditions reactivity. And investigated the effect of NFA to HHPV.</p><p><b>RESULTS</b>(1) Under the hypoxia hypercapnia condition, we observed a biphasic pulmonary artery contractile (the phase I rapid contraction and vasodilation; the phase II sustained contraction) response in both the second and the third branch pulmonary artery rings compared with the control group (P < 0.05 , P < 0.01); (2) The second and third pulmonary artery rings incubated by NFA which phase II persistent vasoconstriction were significantly attenuated compared with the H group (P < 0.05 , P < 0.01).</p><p><b>CONCLUSION</b>The blocker of the chloride channels attenuates the second and third branch pulmonary artery rings constriction in rat, especially the phase II persistent vasoconstriction, so then have an antagonistic effect on HHPV.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Pulmonary Artery / Rats / Vasoconstriction / Niflumic Acid / Pulmonary Circulation / Chloride Channels / Hypercapnia / Animals / Hypoxia Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Pulmonary Artery / Rats / Vasoconstriction / Niflumic Acid / Pulmonary Circulation / Chloride Channels / Hypercapnia / Animals / Hypoxia Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2014 Type: Article