Trauma and pulmonary thromboembolism: an experimental study on their correlation / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 237-241, 2007.
Article
in English
| WPRIM
| ID: wpr-236774
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between trauma and pulmonary thromboembolism.</p><p><b>METHODS</b>Comminuted fractures and extensive soft-tissue contusion at both hind limbs were made by a falling weight from a height in 16 rabbits. Lung perfusion scanning was performed to obtain the radioactivity counts before trauma, at 1 h, 48 h and 96 h after trauma. All the data were divided into 4 groups based on the above 4 time points. The rabbits were sacrificed when positive findings on the pulmonary perfusion scanning appeared. Their lungs were harvested to be paraffin-embedded and stained with hematoxylin-erosin method for histological examination of thromboembolism. The randomized block design ANOVA and the method of least significant difference (LSD) were used for statistical analysis of the radioactivity counts.</p><p><b>RESULTS</b>The histological findings showed that pulmonary embolism developed in 6 of the 16 rabbits (37.5%). Five of the 6 pulmonary embolism rabbits presented neither clinical symptoms nor positive pulmonary embolism manifestations in the lung perfusion scanning. A significant difference was found in lung perfusion radioactivity between the pre-traumatic, post-traumatic 1h groups and post-traumatic 48 h and 96 h groups(P less than 0.05).</p><p><b>CONCLUSIONS</b>Fractures of the hind limbs accompanied with extensive soft-tissue contusion may cause pulmonary micro-embolism that is not sensitive to lung perfusion scanning and tends to have no clinical symptoms. Pulmonary embolism development may take more than two days after trauma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Embolism
/
Wounds and Injuries
/
Fractures, Bone
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2007
Type:
Article
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