Risk factors for parenteral nutrition-associated cholestasis in preterm infants / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 254-258, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-236826
ABSTRACT
<p><b>OBJECTIVE</b>To investigate risk factors for parenteral nutrition-associated cholestasis (PNAC) in preterm infants.</p><p><b>METHODS</b>A retrospective case-control study was performed on 244 preterm infants who received parenteral nutrition (PN) for over 14 days from January 2000 to October 2011.</p><p><b>RESULTS</b>Compared with those without PNAC (n=221), preterm infants with PNAC (n=23) had a longer total duration of PN, a higher total amino acid intake, a higher total lipid intake, a higher maximum daily amino acid intake, a higher maximum daily lipid intake, a higher intravenous calorie intake on the 14th day of PN, a lower birth weight and higher incidence rates of neonatal infection and anemia. Compared with those with PNAC, preterm infants without PNAC who showed a higher total amino acid intake also had a higher total lipid intake, a longer total duration of PN, a higher rate of mechanical ventilation and a lower gestational age. The preterm infants without PNAC who showed a higher total lipid intake also had a lower gestational age. Preterm infants without PNAC who showed a longer total duration of PN also had a lower gestational age.</p><p><b>CONCLUSIONS</b>Total duration of PN, total amino acid intake, maximum daily amino acid intake, total lipid intake, maximum daily lipid intake, intravenous calorie intake on the 14th day of PN, low birth weight, and neonatal infection and anemia are the risk factors for PNAC. Other risk factors need further investigation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Energy Intake
/
Infant, Premature
/
Dietary Fats
/
Case-Control Studies
/
Cholestasis
/
Retrospective Studies
/
Risk Factors
/
Parenteral Nutrition
/
Amino Acids
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Type:
Article
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