Association of tumor necrosis factor-alpha gene polymorphisms with Henoch-Schonlein purpura nephritis in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 88-90, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-236865
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship of tumor necrosis factor-alpha (TNF-α)-308G/A gene polymorphisms with Henoch-Schonlein purpura nephritis (HSPN) in children.</p><p><b>METHODS</b>Using the direct DNA sequencing method, polymorphisms in the TNF-α promoter region (-308) were genotyped in 110 Han children with Henoch-Schonlein purpura (HSP group), including 52 children with nephritis and 58 children without nephritis. Plasma TNF-α levels were measured using ELISA. Ninety ethnically matched healthy children were used as the control group.</p><p><b>RESULTS</b>There were no significant differences in the polymorphisms of TNF-α (-308G/A) between the HSP and control groups (P>0.05). The GA genotype (29% vs 10%) and A allele frequency (18% vs 7%) in HSP children with nephritis (HSPN) were more common than in those without nephritis (P<0.05). Plasma TNF-α levels in HSPN children with GA+AA genotype (7.1±2.3 pg/mL) were significantly higher than those with GG genotype (5.7±1.5 pg/mL) (P<0.05).</p><p><b>CONCLUSIONS</b>TNF-α-308GA genotype and A allele may contribute to the increased risk for the development of nephritis in children with HSP.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
IgA Vasculitis
/
Tumor Necrosis Factor-alpha
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Type:
Article
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