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Impact of number of retrieved lymph nodes and lymph node ratio on the prognosis in patients with stage II and III colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 249-253, 2011.
Article in Chinese | WPRIM | ID: wpr-237136
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the impact of number of retrieved lymph nodes and lymph node ratio(LNR) on the prognosis in patients with stage II and III colorectal cancer.</p><p><b>METHODS</b>Clinicopathological data of 507 patients with stage II and III colorectal cancer were analyzed retrospectively. Follow-up was available in all the patients.</p><p><b>RESULTS</b>The total number of retrieved lymph nodes was 5801, of which 1122 had metastasis. There was a positive correlation between metastatic lymph nodes and retrieved lymph nodes(r=0.171, P<0.01). In stage II colorectal cancer there was a significant difference in 5-year survival rate between patients with more than 12 lymph nodes retrieved and those with less than 12 lymph nodes retrieved(P<0.01). LNR also affected the 5-year survival rate of patients with stage II and III colorectal cancer(P<0.05). In patients with similar LNR, the 5-year survival rate differed significantly among different regions of lymph node metastasis(P<0.05). LNR influenced the prognosis independent of the number of lymph nodes retrieved.</p><p><b>CONCLUSIONS</b>The number of retrieved lymph nodes is a prognostic factor for stage II and III colorectal cancer. More than 12 lymph nodes should be retrieved for better staging and prognosis. LNR is also a prognostic factor in stage II and III colorectal cancer. Regions of lymph nodes metastasis should be considered when evaluating the prognosis of patients using LNR.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / General Surgery / Colorectal Neoplasms / Retrospective Studies / Follow-Up Studies / Diagnosis / Lymph Nodes / Lymphatic Metastasis / Neoplasm Staging Type of study: Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / General Surgery / Colorectal Neoplasms / Retrospective Studies / Follow-Up Studies / Diagnosis / Lymph Nodes / Lymphatic Metastasis / Neoplasm Staging Type of study: Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2011 Type: Article