Effect of Campath-1H induction on immunosuppression in small intestine transplantation / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 199-201, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-237142
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Campath-1H induction on immunosuppression in small intestine transplantation.</p><p><b>METHODS</b>Clinical data of a patient who underwent small intestine transplantation were retrospectively summarized.</p><p><b>RESULTS</b>Intraoperative Campath-1H induction by intravenous injection was administered. Triple immunosuppression(FK506, MMF and methylprednisolone) was used postoperatively. The lymphocyte and leukocyte decreased significantly following Campath-1H induction, and returned to normal after adjusting the dose of immunosuppressant and use of colony stimulating factor. There were no acute rejection, graft versus host disease, or severe infection during the immediate postoperative period. The patient recovered and discharged.</p><p><b>CONCLUSION</b>Intraoperative Campath-1H induction and postoperative triple immunosuppression using FK506, MMF, and methylprednisolone may prevent rejection and graft versus host disease in the early stage after small intestine transplantation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Retrospective Studies
/
Immunosuppression Therapy
/
Therapeutic Uses
/
Antibodies, Monoclonal, Humanized
/
Alemtuzumab
/
Graft Rejection
/
Immunosuppressive Agents
/
Intestine, Small
Type of study:
Observational study
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2011
Type:
Article
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