Expression and clinical significance of epidermal growth factor receptor and protein kinase B in gastric carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 140-142, 2011.
Article
in Zh
| WPRIM
| ID: wpr-237153
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association between survival and expressions of epidermal growth factor receptor(EGFR) and protein kinase B(AKT) in gastric carcinoma specimens.</p><p><b>METHODS</b>EGFR and AKT were detected by immunohistochemistry in 84 patients with gastric cancer and 15 controls. Association between their expressions and clinical characteristics as well as prognosis were analyzed.</p><p><b>RESULTS</b>In patients with gastric cancer,expression rates were significantly higher than those in 15 normal gastric tissues for EGFR(55.9% vs. 20%, P<0.05) and AKT(64.3% vs. 6.7%, P<0.01). Expression of EGFR was associated with late staging(P<0.01), while expression of AKT was associated with lymph node metastasis(P<0.01). Overall 5-year survival rate was significantly higher in patients with EGFR negative expression (49.0% vs. 22.0%, P<0.05). Overall 5-year survival rate was significantly higher in patients with AKT expression(45.7% vs. 30.2%, P<0.05).</p><p><b>CONCLUSION</b>Expression of EGFR and AKT negative may be used to evaluate the degree of differentiation and prognosis in patients with gastric carcinoma.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
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Stomach Neoplasms
/
Chi-Square Distribution
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Proto-Oncogene Proteins c-akt
/
Kaplan-Meier Estimate
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ErbB Receptors
/
Metabolism
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2011
Type:
Article